Endocrine Abstracts

Introduction: The clinical presentation of a secretory pituitary macroadenoma usually consists of a tumor syndrome accompanied by visual disturbances with signs of pituitary insufficiency and/or hormonal hypersecretion. Herein we describe an unusual presentation of a mixed secretory adenoma.Observation: A 69-year-old was referred to our department for the management of a pituitary macroadenoma revealed by a symptomatology mimicking the Hakim Adams triad ...

Introduction: Poorly controlled hypothyroidism is a chronic disease frequently associated with an impaired quality of life (QoL). However, persistent symptoms may be observed in well-controlled hypothyroid patients, impacting their QoL. The aim of our study was to assess the QoL in patients with well-controlled primary hypothyroidism and to evaluate the relationship between the TSH level and the QoL.Methods: A cross-sectional study was conducted in the o...

Introduction: Metformin is the first-line treatment of type 2 diabetes mellitus. Poor adherence can be lead to poor glycemic control. The aim of our study was to determine the level of metformin adherence and its link with glycemic control in type 2 diabetic patients.Methods: We performed a cross-sectional study including 273 patients with type 2 diabetes taking metformin for at least three years. We assessed metformin adherence using the Girerd question...

Introduction: Insulin allergy is a clinical challenge in the management of type 1 diabetes mellitus since there is no other therapeutic alternative. The specific cause of insulin allergy can be related to insulin itself or to additives including zinc, protamine and meta-cresol. The manifestations range from localized reactions to systemic severe anaphylaxis. We here present the case of a generalized allergy to insulin excipient meta-cresol, in a type 1 diabetic patient success...

Plurihormonal pituitary adenomas represent 10-15% of all functioning pituitary adenomas. Functioning ACTH-GH pituitary adenomas constitute an extremely rare entity. Most patients present a clinically manifested acromegaly and subclinical Cushing’s disease. We present the case of a 14 years old female who referred to the endocrinology department for inaugural diabetic ketosis. She had a six-month history of amenorrhea and headaches. On examination, she had facial dysmporph...

Introduction: Non-functional pituitary adenomas (NFPAs) represent 30% of all pituitary adenomas and not associated with clinical evidence of hormonal hypersecretion. The aim of our study was to describe the clinical and paraclinical aspects of NFPAs.Methods: This is a retrospective descriptive study concerning 40 patients who were hospitalized in the endocrinology department of Rabta hospital in Tunis between January 2014 and December 2020. Clinical and ...

Introduction: Gynecomastia is defined as the benign proliferation of the mammary glands in males, which results from an excess of estrogens, androgen deficiency, hormone resistance, or altered ratio of estrogens to androgens. It can be unilateral or bilateral. The aim of our study was to describe the therapeutic aspects and the evolution of gynecomastia.Methods: This is a retrospective descriptive study of 100 patients who presented with gynecomastia at ...

Introduction: Swyer syndrome is a rare sex development disorder characterized by pure 46 XY gonadal dysgenesis. It is associated with aberrations in testicular determination and differentiation leading to a female morphotype with presence of external and internal female genitalia, undifferentiated fibrous gonads, a male karyotype and hypergonadotropic hypogonadism. We present the case of a 46 XY adolescent female with complete gonadal dysgenesis diagnosed following her hospita...

Introduction: Hirsutism is described as excessive development of facial and body hair in women in androgen-dependent areas. Our aim was to determine the clinical and metabolic aspects of hirsutism and its relationship with the metabolic syndrome.Methods: We conducted a retrospective descriptive study at the endocrinology department of Rabta Hospital in Tunis. We recruited 100 women who presented with hirsutism between January 2009 and December 2020 Clini...

Introduction: There is an association between Moyamoya syndrome and Graves’ disease, described primarily in Asian populations. We report a case of Moyamoya vasculopthy with stroke and hypertension associated with graves’ disease in a 15-year-old Tunisian girl.Observation: A 15-year-old girl diagnosed with Moyamoya vasculopathy was referred to the endocrinology department for hyperthyroidism. The patient had a history of recurrent stroke and hyp...